He does not care . . . . . . . . losing his job. A. about B. in C. of D. on

The correct answer is A. about.

The preposition “about” is used to express concern or interest in something. In this case, the speaker is saying that the person does not care about losing his job. This could mean that he is not worried about losing his job, or that he does not think it is a big deal.

The other options are not as appropriate in this context. The preposition “in” is used to express a location or position. The preposition “of” is used to express possession or ownership. The preposition “on” is used to express

Here are some examples of how the preposition “about” can be used:

• I’m worried about my job.
• I’m curious about your new car.
• I’m excited
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  about the party tonight.
• I’m not sure about what to do.

I hope this helps! Let me know if you have any other questions.