Because of a family feud, he never spoke to his wife’s parents.

In the given example, the man never spoke to his wife’s parents because of a family feud. This suggests that the feud was a serious problem that had a significant impact on his life.

The other options are not as accurate as “problem.”

• “Quarrel” is a disagreement that is usually short-lived. It is not as serious as a feud.
• “Crisis” is a situation that is very difficult or dangerous. It is not as common as a feud.
• “Trouble” is a general term for difficulty or problems. It is not as specific as “feud.”