{"id":91894,"date":"2025-06-01T11:08:40","date_gmt":"2025-06-01T11:08:40","guid":{"rendered":"https:\/\/exam.pscnotes.com\/mcq\/?p=91894"},"modified":"2025-06-01T11:08:40","modified_gmt":"2025-06-01T11:08:40","slug":"in-the-context-of-hereditary-diseases-consider-the-following-statemen","status":"publish","type":"post","link":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/","title":{"rendered":"In the context of hereditary diseases, consider the following statemen"},"content":{"rendered":"<p>In the context of hereditary diseases, consider the following statements :<\/p>\n<ul>\n<li>Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg.<\/li>\n<li>A child inherits mitochondrial diseases entirely from mother and not from father.<\/li>\n<\/ul>\n<p>Which of the statements given above is\/are correct?<\/p>\n<p>[amp_mcq option1=&#8221;1 only&#8221; option2=&#8221;2 only&#8221; option3=&#8221;Both 1 and 2&#8243; option4=&#8221;Neither 1 nor 2&#8243; correct=&#8221;option3&#8243;]<\/p>\n<div class=\"psc-box-pyq-exam-year-detail\">\n<div class=\"pyq-exam\">\n<div class=\"psc-heading\">This question was previously asked in<\/div>\n<div class=\"psc-title line-ellipsis\">UPSC IAS &#8211; 2021<\/div>\n<\/div>\n<div class=\"pyq-exam-psc-buttons\"><a href=\"\/pyq\/pyq-upsc-ias-2021.pdf\" target=\"_blank\" class=\"psc-pdf-button\" rel=\"noopener\">Download PDF<\/a><a href=\"\/pyq-upsc-ias-2021\" target=\"_blank\" class=\"psc-attempt-button\" rel=\"noopener\">Attempt Online<\/a><\/div>\n<\/div>\n<section id=\"pyq-correct-answer\">\nStatement 1 is correct, and statement 2 is correct.<br \/>\n<\/section>\n<section id=\"pyq-key-points\">\n&#8211; Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother&#8217;s egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization).<br \/>\n&#8211; Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.<br \/>\n<\/section>\n<section id=\"pyq-additional-information\">\nMitochondrial diseases are a group of chronic, genetic disorders that occur when mitochondria fail to produce enough energy for the body to function properly. MRT is a relatively new and complex technique with ethical and regulatory considerations, approved in some countries under specific conditions.<br \/>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>In the context of hereditary diseases, consider the following statements : Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg. A child inherits mitochondrial diseases entirely from mother and not from father. Which of the statements given above is\/are correct? &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"In the context of hereditary diseases, consider the following statemen\" class=\"read-more button\" href=\"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/#more-91894\">Detailed Solution<span class=\"screen-reader-text\">In the context of hereditary diseases, consider the following statemen<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1092],"tags":[1110,1117,1441],"class_list":["post-91894","post","type-post","status-publish","format-standard","hentry","category-upsc-ias","tag-1110","tag-biology","tag-genetic-disorders","no-featured-image-padding"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.2 (Yoast SEO v23.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>In the context of hereditary diseases, consider the following statemen<\/title>\n<meta name=\"description\" content=\"Statement 1 is correct, and statement 2 is correct. - Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother&#039;s egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization). - Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In the context of hereditary diseases, consider the following statemen\" \/>\n<meta property=\"og:description\" content=\"Statement 1 is correct, and statement 2 is correct. - Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother&#039;s egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization). - Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/\" \/>\n<meta property=\"og:site_name\" content=\"MCQ and Quiz for Exams\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-01T11:08:40+00:00\" \/>\n<meta name=\"author\" content=\"rawan239\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"rawan239\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"In the context of hereditary diseases, consider the following statemen","description":"Statement 1 is correct, and statement 2 is correct. - Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother's egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization). - Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/","og_locale":"en_US","og_type":"article","og_title":"In the context of hereditary diseases, consider the following statemen","og_description":"Statement 1 is correct, and statement 2 is correct. - Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother's egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization). - Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.","og_url":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/","og_site_name":"MCQ and Quiz for Exams","article_published_time":"2025-06-01T11:08:40+00:00","author":"rawan239","twitter_card":"summary_large_image","twitter_misc":{"Written by":"rawan239","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/","url":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/","name":"In the context of hereditary diseases, consider the following statemen","isPartOf":{"@id":"https:\/\/exam.pscnotes.com\/mcq\/#website"},"datePublished":"2025-06-01T11:08:40+00:00","dateModified":"2025-06-01T11:08:40+00:00","author":{"@id":"https:\/\/exam.pscnotes.com\/mcq\/#\/schema\/person\/5807dafeb27d2ec82344d6cbd6c3d209"},"description":"Statement 1 is correct, and statement 2 is correct. - Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother's egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization). - Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.","breadcrumb":{"@id":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/exam.pscnotes.com\/mcq\/in-the-context-of-hereditary-diseases-consider-the-following-statemen\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/exam.pscnotes.com\/mcq\/"},{"@type":"ListItem","position":2,"name":"UPSC IAS","item":"https:\/\/exam.pscnotes.com\/mcq\/category\/upsc-ias\/"},{"@type":"ListItem","position":3,"name":"In the context of hereditary diseases, consider the following statemen"}]},{"@type":"WebSite","@id":"https:\/\/exam.pscnotes.com\/mcq\/#website","url":"https:\/\/exam.pscnotes.com\/mcq\/","name":"MCQ and Quiz for Exams","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/exam.pscnotes.com\/mcq\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/exam.pscnotes.com\/mcq\/#\/schema\/person\/5807dafeb27d2ec82344d6cbd6c3d209","name":"rawan239","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/exam.pscnotes.com\/mcq\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/761a7274f9cce048fa5b921221e7934820d74514df93ef195a9d22af0c1c9001?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/761a7274f9cce048fa5b921221e7934820d74514df93ef195a9d22af0c1c9001?s=96&d=mm&r=g","caption":"rawan239"},"sameAs":["https:\/\/exam.pscnotes.com"],"url":"https:\/\/exam.pscnotes.com\/mcq\/author\/rawan239\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/posts\/91894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/comments?post=91894"}],"version-history":[{"count":0,"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/posts\/91894\/revisions"}],"wp:attachment":[{"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/media?parent=91894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/categories?post=91894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/exam.pscnotes.com\/mcq\/wp-json\/wp\/v2\/tags?post=91894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}