The correct answer is: A. Sunita Williams
Sunita Williams is an American astronaut and United States Navy officer. She is the first Indian-American woman and the fourth woman of Indian origin to go into space. She has logged over 322 days in space on four Space Shuttle missions.
Kalpana Chawla was an Indian-American astronaut and the first woman of Indian origin in space. She was killed in the Space Shuttle Columbia disaster in 2003.
Mrinal Sarabhai was an Indian nuclear physicist and the first woman in India to receive a doctorate in physics. She was the wife of Vikram Sarabhai, the father of the Indian space program.
None of the above options are the first woman astronaut of Gujarati origin.