The wheels of the truck press . . . . . . . . the road? A. on B. against C. upon D. over

The correct answer is: A. on

The wheels of the truck press on the road.

• On means in contact with the surface of something.
• Against means in opposition to something.
• Upon means on top of something.
• Over means above or across something.

In this case, the wheels of the truck are in contact with the surface of the road, so the correct answer is on.