The district headquarters of Karimnagar district is:

Mancherial
Jagtial
Karimnagar
Peddapalli

The correct answer is C. Karimnagar.

Karimnagar is a city and district headquarters of Karimnagar district in the Indian state of Telangana. It is located on the banks of the Manair River, about 200 kilometers (120 mi) north of Hyderabad, the state capital. The city is a major commercial and industrial center in Telangana. It is also home to a number of educational institutions, including the University of Karimnagar.

The district of Karimnagar is one of the largest districts in Telangana. It is bounded by the districts of Warangal to the north, Khammam to the east, Adilabad to the south, and Nizamabad to the west. The district has a population of over 3 million people.

The district of Karimnagar is a major producer of rice, cotton, and tobacco. It is also home to a number of industries, including steel, textiles, and chemicals. The district is well-connected by road and rail to other parts of Telangana and the rest of India.

The district of Karimnagar is a popular tourist destination. The city of Karimnagar is home to a number of historical monuments, including the Karimnagar Fort, the Karimnagar Palace, and the Karimnagar Mosque. The district is also home to a number of temples, including the Sri Laxmi Narasimha Swamy Temple, the Sri Venkateswara Swamy Temple, and the Sri Hanuman Temple.

The district of Karimnagar is a beautiful and culturally rich region. It is a popular tourist destination and a major commercial and industrial center.