The chemical properties of an element depend upon

The chemical properties of an element depend upon

the number of isotopes of the element
the mass number of the element
the total number of neutrons in the element
the number of electrons in the outermost shell of the element
This question was previously asked in
UPSC CDS-1 – 2017
The chemical properties of an element are determined by its electronic configuration, specifically the number and arrangement of electrons in the outermost shell (valence shell). These valence electrons are involved in chemical bonding and reactions.
Statements A, B, and C relate to the nucleus and mass of the atom. The number of isotopes (A), mass number (B), and number of neutrons (C) affect the physical properties (like density, melting point, boiling point, radioactive decay) but generally do not significantly alter the chemical behavior of an element.
Elements in the same group of the periodic table have similar chemical properties because they have the same number of valence electrons. This highlights the fundamental role of the outermost electrons in determining chemical behavior.