Sometimes we have to put . . . . . . . . with something irksome or unpleasant.

The correct answer is: up.

To “put up with” something means to tolerate it, even though it is difficult or unpleasant. For example, you might say “I’m putting up with my noisy neighbors because I can’t afford to move.”

The other options do not make sense in this context. “Put on” means to put something on your body, such as clothes or a hat. “Put in” means to put something inside something else, such as a coin in a slot machine or a letter in an envelope. “Put off” means to postpone something, such as a meeting or a trip.

I hope this helps!