She is good . . . . . . . . Mathematics. A. from B. in C. at D. on

from
in
at
on

The correct answer is “in”.

The preposition “in” is used to indicate a subject’s skill or expertise in a particular area. In this case, the subject is “she” and the area of expertise is “Mathematics”. Therefore, the correct preposition to use is “in”.

The other options are not correct because they do not indicate a subject’s skill or expertise in a particular area. The preposition “from” is used to indicate a subject’s origin or source. The preposition “at” is used to indicate a subject’s location or position. The preposition “on” is used to indicate a subject’s position on a surface or in a location.