The correct answer is: C. Important when replication is impossible.
Reproducibility is the ability to produce the same results from the same methods, materials, and conditions. It is a key component of the scientific method, as it allows researchers to verify the validity of their findings. Replication is important because it helps to ensure that the results of a study are not due to chance or bias.
However, replication is not always possible. For example, it may be difficult or impossible to replicate a study that used a unique sample or a complex experimental design. In these cases, reproducibility can be used as an alternative. Reproducibility focuses on the validity of the data analysis, rather than the ability to produce the same results. This can be done by carefully documenting the methods used to collect and analyze the data, and by making the data and analysis code available to other researchers.
Therefore, option C is the wrong statement with respect to reproducibility.