In the context of vaccines manufactured to prevent COVID-19 pandemic,

In the context of vaccines manufactured to prevent COVID-19 pandemic, consider the following statements:

  • The Serum Institute of India produced COVID-19 vaccine named Covishield using mRNA platform.
  • Sputnik V vaccine is manufactured using vector based platform.
  • COVAXIN is an inactivated pathogen based vaccine.

Which of the statements given above are correct ?

1 and 2 only
2 and 3 only
1 and 3 only
1, 2 and 3
This question was previously asked in
UPSC IAS – 2022
Statements 2 and 3 are correct. Statement 1 is incorrect.
– Statement 1 is incorrect: Covishield, manufactured by the Serum Institute of India, is the Oxford-AstraZeneca vaccine. It uses a viral vector platform (specifically, a modified chimpanzee adenovirus) to deliver the genetic material for the SARS-CoV-2 spike protein. It is not an mRNA vaccine.
– Statement 2 is correct: Sputnik V, developed by the Gamaleya Research Institute in Russia, is an adenoviral vector vaccine. It uses two different human adenoviruses (Ad26 and Ad5) for the two doses.
– Statement 3 is correct: COVAXIN, developed by Bharat Biotech in India, is an inactivated pathogen-based vaccine. It uses the whole SARS-CoV-2 virus, which has been chemically inactivated so it cannot replicate or cause disease, but can still trigger an immune response.
COVID-19 vaccines utilize various platforms, including mRNA (e.g., Pfizer-BioNTech, Moderna), viral vector (e.g., AstraZeneca/Covishield, Sputnik V, Johnson & Johnson), inactivated virus (e.g., COVAXIN, Sinovac, Sinopharm), and protein subunit. Understanding the platform is key to knowing how the vaccine works.