In the context of recent advances in human reproductive technology, “P

by

In the context of recent advances in human reproductive technology, “Pronuclear Transfer” is used for

fertilization of egg in vitro by the donor sperm
genetic modification of sperm producing cells
development of stem cells into functional embryos
prevention of mitochondrial diseases in offspring
This question was previously asked in
UPSC IAS – 2020
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Pronuclear Transfer is a technique used in assisted reproductive technology aimed at preventing the transmission of mitochondrial diseases from a mother to her child. It involves transferring the nuclear genetic material (contained in the pronuclei after fertilization) from the intended parents’ fertilized egg into a donor egg that has healthy mitochondria but has had its own nucleus removed. This creates a zygote with the intended parents’ nuclear DNA and the donor’s mitochondrial DNA, which can then be implanted.
Pronuclear Transfer is a method specifically designed to prevent the inheritance of mitochondrial diseases.
This technique is sometimes referred to as ‘three-parent IVF’ because the resulting child effectively has genetic material from three individuals: nuclear DNA from both parents and mitochondrial DNA from a donor. Another related technique is Maternal Spindle Transfer.

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