The correct answer is: A. Once a week.
The BD Spl is a type of blood filter that is used to remove waste products and toxins from the blood. It is a small, disposable device that is inserted into a vein in the arm. The BD Spl must be filled with fresh, sterile saline solution every week to ensure that it is working properly.
Option B is incorrect because the BD Spl should be filled with fresh, sterile saline solution every week, not every two weeks.
Option C is incorrect because the BD Spl should be filled with fresh, sterile saline solution every week, not every three weeks.
Option D is incorrect because the BD Spl must be filled with fresh, sterile saline solution every week.