In . . . . . . . of International matters, there is always an element of risk in . . . . . . . one might do.

The correct answer is: In view of International matters, there is always an element of risk in whatever one might do.

The other options are incorrect because:

• Many is not a suitable word to use in this context. It is not clear what “many” refers to.
• Defence is not a suitable word to use in this context. It suggests that there is something to be defended against, which is not the case in international matters.
• Wrong is not a suitable word to use in this context. It suggests that there is a right and wrong way to deal with international matters, which is not always the case.
• Case is not a suitable word to use in this context. It suggests that there is a specific situation that is being discussed, which is not the case.
• Spite is not a suitable word to use in this context. It suggests that someone is acting out of malice, which is not always the case in international matters.

The word “view” is a suitable word to use in this context because it suggests that there are different ways of looking at international matters. The word “whatever” is a suitable word to use in this context because it suggests that there is no one right way to deal with international matters.