From which among the following are blood clotting factors released?

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RBCs

Eosinophils

Platelets

Monocytes

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UPSC CDS-1 – 2024

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The correct option is C) Platelets.

While most blood clotting factors are proteins produced in the liver and circulated in the plasma, platelets (thrombocytes) play a critical role in initiating and facilitating the coagulation cascade at the site of injury. When a blood vessel is damaged, platelets adhere to the damaged endothelium, aggregate to form a plug, and release various substances, including platelet factors (like platelet factor 3/tissue factor), that are essential for activating and accelerating the steps of the clotting cascade.

The clotting cascade is a complex process involving numerous protein factors (Factor I to Factor XIII, and others like tissue factor). Platelets provide a negatively charged surface (via exposed phospholipids) that is crucial for the assembly and activation of several key clotting factor complexes, significantly enhancing the efficiency of clot formation.

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