Dengue virus is known to cause low platelet count in blood of patient

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Dengue virus is known to cause low platelet count in blood of patient by :

  • 1. interfering in the process of platelet production in bone marrow
  • 2. infecting endothelial cells
  • 3. binding with platelets
  • 4. accumulating platelets in intestine

Select the correct answer using the code given below :

1 and 2 only
1 and 3 only
3 and 4
1, 2 and 3
This question was previously asked in
UPSC CDS-1 – 2016
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Dengue virus can cause low platelet count through multiple mechanisms including interfering with platelet production, infecting endothelial cells, and binding with platelets.
Dengue-induced thrombocytopenia is multifactorial. Mechanisms include suppression of bone marrow (statement 1), direct or indirect damage to endothelial cells leading to increased platelet consumption (statement 2), immunological destruction of platelets through antibody cross-reaction or binding of viral/immune complexes to platelets leading to their removal (statement 3). Accumulation of platelets in the intestine (statement 4) is not a known primary mechanism of dengue-induced thrombocytopenia.
Thrombocytopenia is a common manifestation of dengue fever and a significant risk factor for hemorrhagic complications, especially in severe dengue.

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