A distinguished physicist from Karnataka who won the Nobel Prize:

C.V. Raman
Homi J. Bhabha
S. Chandrasekhar
Vikram Sarabhai

The correct answer is C.V. Raman.

C.V. Raman was a physicist who was born in Tiruchirapalli, Tamil Nadu, India in 1888. He is best known for his discovery of the Raman effect, which is the scattering of light by matter. He was awarded the Nobel Prize in Physics in 1930 for this discovery.

Homi J. Bhabha was a nuclear physicist who was born in Mumbai, Maharashtra, India in 1909. He is best known for his work on the development of nuclear power in India. He was the founder of the Indian Atomic Energy Commission and the Tata Institute of Fundamental Research.

S. Chandrasekhar was an astrophysicist who was born in Lahore, Punjab, British India (now in Pakistan) in 1910. He is best known for his work on the Chandrasekhar limit, which is the maximum mass that a stable star can have. He was awarded the Nobel Prize in Physics in 1983 for this work.

Vikram Sarabhai was a space scientist who was born in Ahmedabad, Gujarat, India in 1919. He is best known for his work on the development of the Indian space program. He was the founder of the Indian Space Research Organisation.

All of these men were distinguished physicists from India, but only C.V. Raman won the Nobel Prize.