In the context of recent advances in human reproductive technology, “P

In the context of recent advances in human reproductive technology, “Pronuclear Transfer” is used for

[amp_mcq option1=”fertilization of egg in vitro by the donor sperm” option2=”genetic modification of sperm producing cells” option3=”development of stem cells into functional embryos” option4=”prevention of mitochondrial diseases in offspring” correct=”option4″]

This question was previously asked in

UPSC IAS – 2020

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Pronuclear Transfer is a technique used in assisted reproductive technology aimed at preventing the transmission of mitochondrial diseases from a mother to her child. It involves transferring the nuclear genetic material (contained in the pronuclei after fertilization) from the intended parents’ fertilized egg into a donor egg that has healthy mitochondria but has had its own nucleus removed. This creates a zygote with the intended parents’ nuclear DNA and the donor’s mitochondrial DNA, which can then be implanted.

Pronuclear Transfer is a method specifically designed to prevent the inheritance of mitochondrial diseases.

This technique is sometimes referred to as ‘three-parent IVF’ because the resulting child effectively has genetic material from three individuals: nuclear DNA from both parents and mitochondrial DNA from a donor. Another related technique is Maternal Spindle Transfer.

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