In vertebrates, smooth endoplasmic reticulum in cells of which organ p

In vertebrates, smooth endoplasmic reticulum in cells of which organ plays a crucial role in detoxification of toxic compounds ?

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Spleen

Intestine

Kidney

Liver

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UPSC CAPF – 2023

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The smooth endoplasmic reticulum (SER) is involved in various metabolic processes, including lipid synthesis, steroid hormone production, and importantly, detoxification of drugs, poisons, and metabolic waste products. In vertebrates, the liver is the primary organ for detoxification, and its cells (hepatocytes) are particularly rich in SER, which contains enzymes like cytochrome P450 that metabolize these toxic compounds, often making them more soluble for excretion.

– Smooth endoplasmic reticulum is involved in detoxification.
– The liver is the main detoxification organ in vertebrates.
– Liver cells (hepatocytes) contain abundant smooth endoplasmic reticulum.

While other organs might have some detoxification capabilities or be involved in elimination (like kidneys), the liver’s role in metabolic detoxification via enzymes located in the SER is crucial and most prominent. The spleen is mainly involved in filtering blood, immune responses, and red blood cell turnover. The intestine is involved in digestion and absorption, and while it has some metabolic activity, its primary role is not systemic detoxification. The kidneys are primarily involved in filtering blood and excreting waste in urine.

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