The Nobel Prize-winning physicist born in Madras (now Chennai) was:

C.V. Raman
Subrahmanyan Chandrasekhar
Amartya Sen
Venkatraman Ramakrishnan

The correct answer is C.V. Raman.

C.V. Raman was born in Madras (now Chennai) in 1888. He was a physicist who won the Nobel Prize in Physics in 1930 for his discovery of the Raman effect. The Raman effect is the scattering of light by matter, which causes the light to change its wavelength. This effect is named after Raman, who first observed it in 1928.

Subrahmanyan Chandrasekhar was born in Lahore (now in Pakistan) in 1910. He was an astrophysicist who won the Nobel Prize in Physics in 1983 for his work on the stability of white dwarf stars.

Amartya Sen was born in Santiniketan, West Bengal, India in 1933. He is an economist who won the Nobel Prize in Economics in 1998 for his work on welfare economics and social choice theory.

Venkatraman Ramakrishnan was born in Chidambaram, Tamil Nadu, India in 1952. He is a biochemist who won the Nobel Prize in Chemistry in 2009 for his work on the structure and function of the ribosome.