The medium of instruction in most government schools in Maharashtra is:

Marathi
English
Hindi
A mix of Marathi and English

The correct answer is: Marathi.

Marathi is the medium of instruction in most government schools in Maharashtra. This is because Marathi is the official language of the state of Maharashtra. The government of Maharashtra has made it mandatory for all government schools to teach in Marathi. However, there are some government schools that offer English as the medium of instruction. These schools are usually located in urban areas where there is a high demand for English-medium education.

Hindi is not the medium of instruction in most government schools in Maharashtra. This is because Hindi is not the official language of the state of Maharashtra. However, Hindi is a widely spoken language in Maharashtra. There are some government schools that offer Hindi as the medium of instruction. These schools are usually located in areas where there is a high concentration of Hindi-speaking people.

A mix of Marathi and English is not the medium of instruction in most government schools in Maharashtra. This is because the government of Maharashtra has made it mandatory for all government schools to teach in Marathi. However, there are some government schools that offer English as a second language. These schools are usually located in urban areas where there is a high demand for English-medium education.