A major port city in Goa is:

Vasco da Gama
Margao
Ponda
Canacona

The correct answer is Vasco da Gama.

Vasco da Gama is a major port city in Goa, India. It is located on the Arabian Sea coast, about 30 kilometers south of Panaji, the state capital. The city was founded in 1510 by the Portuguese explorer Vasco da Gama, after whom it is named. Vasco da Gama is a major commercial and industrial center, and is home to a number of industries, including textiles, chemicals, and food processing. The city is also a popular tourist destination, with a number of beaches, temples, and churches.

Margao is the second largest city in Goa, and is located in the south of the state. The city is a major commercial and industrial center, and is home to a number of industries, including textiles, chemicals, and food processing. Margao is also a popular tourist destination, with a number of beaches, temples, and churches.

Ponda is a city in the central part of Goa. The city is a major religious and cultural center, and is home to a number of temples and churches. Ponda is also a popular tourist destination, with a number of beaches and historical sites.

Canacona is a town in the south of Goa. The town is a popular tourist destination, with a number of beaches, temples, and churches.