The famous Minamata disease in Japan is due to the accumulation of____________in fishes.

Cadmium
Mercury
Zinc
Lead

The correct answer is B. Mercury.

Minamata disease is a neurological disorder caused by mercury poisoning. It was first identified in Minamata, Japan, in 1956, after people who ate fish from Minamata Bay began to suffer from a variety of symptoms, including numbness in the extremities, loss of coordination, and impaired vision and hearing. The disease is caused by the accumulation of mercury in the body, which can occur through eating fish or shellfish that have been contaminated with mercury. Mercury can also be absorbed through the skin or inhaled.

The main source of mercury contamination in Minamata Bay was a chemical factory that was dumping mercury-containing waste into the bay. The factory was not aware of the dangers of mercury pollution, and it continued to dump waste into the bay until it was shut down in 1968.

Minamata disease is a serious and often fatal condition. There is no cure for the disease, but treatment can help to relieve symptoms. Treatment may include chelation therapy, which is a process that removes mercury from the body.

Cadmium, zinc, and lead are also toxic metals, but they are not known to cause Minamata disease.