{"id":15500,"date":"2025-04-11T13:39:55","date_gmt":"2025-04-11T13:39:55","guid":{"rendered":"https:\/\/exam.pscnotes.com\/current-affairs\/?p=15500"},"modified":"2025-04-11T13:41:47","modified_gmt":"2025-04-11T13:41:47","slug":"sickle-cell-disease","status":"publish","type":"post","link":"https:\/\/exam.pscnotes.com\/current-affairs\/sickle-cell-disease\/","title":{"rendered":"Sickle Cell Disease"},"content":{"rendered":"<ul>\n<li><strong>RRI&#8217;s Affordable Screening Device:<\/strong> Raman Research Institute (RRI) has developed a cost-effective electro-fluidic device for preliminary screening of Sickle Cell Disease (SCD).<\/li>\n<li><strong>High-Resolution Stiffness Measurement:<\/strong> The device quantifies whole-cell stiffness with high resolution and throughput, differentiating SCD and healthy donor RBCs with high precision.<\/li>\n<li><strong>How it Works:<\/strong> The device measures cell volume and stiffness in free-flight and constricted-flight modes, correlating flight time with cellular stiffness.<\/li>\n<li><strong>Potential Impact:<\/strong> This technology could change diagnostic methods for blood disorders, offering a rapid way to detect mechanical abnormalities in RBCs. Its portability and cost-efficiency make it suitable for mass-screening in both rural and urban areas.<\/li>\n<li><strong>Beyond SCD:<\/strong> Whole cell stiffness measurements have applications in tumor cell detection and veterinary blood disorders. The device principle could also be applied to improve hydrogel materials for drug delivery systems.<\/li>\n<li><strong>SCD Basics:<\/strong> SCD is an inherited blood disorder affecting red blood cells (RBCs) due to flawed hemoglobin. Sickled RBCs block blood flow, causing pain, organ damage, anemia, and other complications.<\/li>\n<li><strong>Inheritance:<\/strong> SCD is caused by inheriting two sickle cell genes (one from each parent).<\/li>\n<li><strong>Symptoms:<\/strong> Include tiredness, swollen hands\/feet, jaundice (early), severe pain, anemia, organ damage, and infections (later).<\/li>\n<li><strong>Treatments:<\/strong> Bone marrow transplant can cure SCD; other treatments relieve symptoms. Gene therapy has been approved in UK.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>RRI&#8217;s Affordable Screening Device: Raman Research Institute (RRI) has developed a cost-effective electro-fluidic device for preliminary screening of Sickle Cell Disease (SCD). High-Resolution Stiffness Measurement: The device quantifies whole-cell stiffness with high resolution and throughput, differentiating SCD and healthy donor RBCs with high precision. How it Works: The device measures cell volume and stiffness in &#8230; <a title=\"Sickle Cell Disease\" class=\"read-more\" href=\"https:\/\/exam.pscnotes.com\/current-affairs\/sickle-cell-disease\/\" aria-label=\"Read more about Sickle Cell Disease\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":15533,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[595],"tags":[1272],"class_list":["post-15500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current-affairs","tag-10-04-25"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.2 (Yoast SEO v23.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sickle Cell Disease - Current Affairs Exam<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/exam.pscnotes.com\/current-affairs\/sickle-cell-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sickle Cell Disease\" \/>\n<meta property=\"og:description\" content=\"RRI&#8217;s Affordable Screening Device: Raman Research Institute (RRI) has developed a cost-effective electro-fluidic device for preliminary screening of Sickle Cell Disease (SCD). 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High-Resolution Stiffness Measurement: The device quantifies whole-cell stiffness with high resolution and throughput, differentiating SCD and healthy donor RBCs with high precision. How it Works: The device measures cell volume and stiffness in ... 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